Visual OMP^TM 6.5 Upgrade Released to All Customers

Ann Arbor, Mich. – July 18, 2008 – DNA Software is pleased to announce the release of Visual OMP^TM 6.5, which now contains the optional ThermoBLAST^TM module.

ThermoBLAST ^TM

Overview:  ThermoBLAST^TM is a paradigm-shifting technology that combines the speed of BLAST with the advanced thermodynamics of OMP^TM.  It quickly and accurately checks probes and primers against whole genomes; identifies potential mishybridizations to unintended targets; determines if such mishybridizations are extensible; eliminates all false positives and negatives; and designs the most sensitive and selective assays.

ThermoBLAST^TM Superior to BLAST:  BLAST was originally designed for evolutionary applications and not for checking probe/primer designs.  BLAST is limited to only exact-match base pairing (i.e. A:T and G:C) and minimum word lengths of 7 nucleotides.  Whereas, ThermoBLAST^TM accounts for actual hybridization and stable mismatches (e.g. G:G, G:T, A:G, etc.) as well as deletions, loops, bulges, etc.  Moreover, it has the ability to discern and quantify nonspecific binding to a single base pair mutation at the genome scale.  ThermoBLAST^TM accounts for temperature, and salt concentrations.  In addition, it provides a quick primer screening option and reports if hits can be extended by DNA polymerase.  ThermoBLAST^TM ranks mishybridization hits; generates thermodynamic and Tm values; and shows secondary structures for each hit. 

 

This significant hybridization with a low dG, high Tm, and extensible 3’ end, is found by ThermoBLAST^TM.  BLAST will not find this hit, since there are not 7 complementary bases in a row (the minimum word-size in BLAST is 7).

Value Proposition:  ThermoBLAST^TM is an efficiency technology that all scientists should consider utilizing while developing their assays.  It will eliminate all false positive and negatives, design the most sensitive and selective assays, and save organizations significant time, money, and resources.

ThermoBLAST Option:  ThermoBLAST^TM is available as an additional option for Visual OMP^TM or OMP Developer Edition^TM.  Within Visual OMP^TM, ThermoBLAST^TM is currently available on the stand-alone BLAST-form, next to the Traditional BLAST tab; it is grayed out for non-licensed users.  DNA Software is offering free trial licenses and WebEx demonstrations on how to use ThermoBLAST^TM to improve your assay design.  For more information on upgrading your system to include ThermoBLAST^TM, please contact DNA Software at +1 734 222-9080 or info@dnasoftware.com.

Visual OMP^TM 6.5 Upgrade Summary

New Features: 

 Enhancements:

1. Several issues with validation of Seq Start and Seq End values on the Sequences tab
2. Saving of default values for the microarray correction
3. Automatic moving and renumbering of variations and modifications when adding or removing nucleotides
4. Saving of changed advanced parameters on the right hand side of the grid
5. Filtering non-IUPAC ambiguity codes when importing sequences from a fasta-file to multiple experiments
   
   For a complete list of all of the features of the new version, please visit our Version History page.   

About DNA Software, Inc.

DNA Software, Inc. combines science and software to enable industrial genomics through advances in technologies based on nucleic acids. The company’s first software platform, OMP^TM (Oligonucleotide Modeling Platform^TM), models in silico the folding and hybridization of nucleic acids with great accuracy. The company combines OMP^TM with scientific consulting, custom software development, and custom laboratory research to deliver state-of-the-art support for designing and developing of nucleic acid based technologies. For more information on DNA Software, Inc., visit our website at http://www.dnasoftware.com or contact us. 

CONTACT:

DNA Software, Inc.
204 East Washington Street
Ann Arbor, MI 48104
Office: +1 (734) 222-9080
Fax: +1 (734) 222-9087
Email: info@dna-software.com 

If you have any questions, please Contact us.